12/4/2023 0 Comments Define pathological fatigue![]() ![]() Fatigue in neurological disorders has been suggested to have a neurobiological origin related to neural circuits that connect the basal ganglia, amygdala, thalamus, and frontal cortex ( Chaudhuri and Behan, 2000, 2004). It can be experienced as physical or cognitive/mental fatigue, and may have different neurobiological and neurophysiologic correlates. It is difficult to define and to measure in an objective manner. However, the fatigue is not always visible externally nor can it be detected or quantified by any blood sample or other test. Changes in other neurotransmitters such as dopamine, serotonin, norepinephrine, GABA, and acetylcholine after brain injury are also taken into consideration.įatigue is one of the most common reasons for people to apply for primary care. In this paper, we extend our previously presented hypothesis on the cellular mechanisms underlying mental fatigue suggesting a dysfunction in the astroglial support of the glutamate transmission. ![]() The astroglial cells are responsible for the fine-tuning of the glutamate transmission, but this capacity is attenuated by substances or conditions associated with neuro-inflammation in brain pathology. Low levels and the fine-tuning of extracellular glutamate are necessary to maintain a high precision in information processing. Glutamate signaling is essential for information processing, including learning and memory. Information processing is energy consuming and requires widespread and specific neural signaling. Mental fatigue after traumatic brain injury correlates with brain information processing speed. It is difficult to go back to work and participate in familiar social activities, as typically the person is only able to remain mentally active for short periods, and if mentally exhausted, the recovery time will be disproportionally long. ![]() Long-lasting mental or cognitive fatigue may be a disabling symptom after physically recovered skull trauma, stroke, infection, or inflammation in the central nervous system (CNS). Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |